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The Research Behind RE·CAL

Every ingredient in the Recal System is backed by published, peer-reviewed clinical research. Below are the key studies our formulation is based on.

Berberine Phytosome (Berbevis®)

Di Pierro F, et al. (2023). "Effect of Berberine Phytosome on reproductive, dermatologic, and metabolic characteristics in women with polycystic ovary syndrome: a controlled, randomized, multi-centric, open-label clinical trial." Frontiers in Pharmacology, 14:1269605. doi: 10.3389/fphar.2023.1269605

Di Pierro F, et al. (2023). "Berberine Phytosome exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose: a randomized double-blind placebo-controlled clinical trial." European Review for Medical and Pharmacological Sciences, 27(8):3483-3490.

Lan J, et al. (2015). "Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension." Journal of Ethnopharmacology, 161:69-81.

Liang Y, et al. (2019). "Effects of berberine on blood glucose in patients with type 2 diabetes: a systematic literature review and meta-analysis." Endocrine Journal, 66(1):51-63.

Eriocitrin (Eriomin®)

Cesar TB, Ramos FMM, Ribeiro CB. (2022). "Nutraceutical Eriocitrin (Eriomin) Reduces Hyperglycemia by Increasing Glucagon-Like Peptide 1 and Downregulates Systemic Inflammation: A Crossover-Randomized Clinical Trial." Journal of Medicinal Food, 25(11):1050-1058. doi: 10.1089/jmf.2021.0181

Ramos FM, et al. (2023). "Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double-blind randomized controlled trial." Food Science & Nutrition, 11(11):7381-7393. doi: 10.1002/fsn3.3654

Ribeiro CB, et al. (2020). "Effect of Eriomin® on Glycemia, Inflammatory and Immunological Biomarkers: A Pilot, Double-Blind, Randomized, Placebo-Controlled Clinical Trial in Patients with Prediabetes." The FASEB Journal, 34(S1):1-1.

Chromium Picolinate

Balk EM, et al. (2007). "Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials." Diabetes Care, 30(8):2154-2163.

Anton SD, et al. (2008). "Effects of chromium picolinate on food intake and satiety." Diabetes Technology & Therapeutics, 10(5):405-412.

Black Pepper Extract (Bioperine®)

Shoba G, et al. (1998). "Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers." Planta Medica, 64(4):353-356.

Badmaev V, et al. (1999). "Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation." Nutrition Research, 19(3):381-388.

Creatine Monohydrate

Kreider RB, et al. (2017). "International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine." Journal of the International Society of Sports Nutrition, 14:18. doi: 10.1186/s12970-017-0173-z

Buford TW, et al. (2007). "International Society of Sports Nutrition position stand: creatine supplementation and exercise." Journal of the International Society of Sports Nutrition, 4:6.

Devries MC, Phillips SM. (2014). "Creatine supplementation during resistance training in older adults — a meta-analysis." Medicine & Science in Sports & Exercise, 46(6):1194-1203.

Hmb (Calcium Beta-hydroxy-beta-methylbutyrate)

Wilson JM, et al. (2013). "International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB)." Journal of the International Society of Sports Nutrition, 10(1):6.

Wu H, et al. (2015). "Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults: a systematic review and meta-analysis." Archives of Gerontology and Geriatrics, 61(2):168-175.

Magnesium Glycinate

Abbasi B, et al. (2012). "The effect of magnesium supplementation on primary insomnia in elderly: a double-blind placebo-controlled clinical trial." Journal of Research in Medical Sciences, 17(12):1161-1169.

Held K, et al. (2002). "Oral Mg2+ supplementation reverses age-related neuroendocrine and sleep EEG changes in humans." Pharmacopsychiatry, 35(4):135-143.

Ashwagandha (Ksm-66®)

Chandrasekhar K, Kapoor J, Anishetty S. (2012). "A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults." Indian Journal of Psychological Medicine, 34(3):255-262. doi: 10.4103/0253-7176.106022

Salve J, et al. (2019). "Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study." Cureus, 11(12):e6466.

Langade D, et al. (2019). "Efficacy and Safety of Ashwagandha Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study." Cureus, 11(9):e5797.

Phosphatidylserine

Monteleone P, et al. (1992). "Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men." European Journal of Clinical Pharmacology, 42(4):385-388.

Starks MA, et al. (2008). "The effects of phosphatidylserine on endocrine response to moderate intensity exercise." Journal of the International Society of Sports Nutrition, 5:11.

Glp-1 Rebound Reference

Shi Q, et al. (2024). "Pharmacological interventions for the treatment of overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials." BMJ, 384:e076765.

Wilding JPH, et al. (2022). "Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension." Diabetes, Obesity and Metabolism, 24(8):1553-1564.

All studies referenced are publicly available in peer-reviewed journals. RE·CAL is not affiliated with any of the research institutions listed above. These studies informed our formulation but were not conducted on the RE·CAL product specifically.